IMRPS: Inserted and Modified Residues in Protein Structures. A database

Modified residues present in proteins are the result of post‐translational modifications (PTMs). These PTMs increase the functional diversity of the proteome and influence various biological processes and diseased conditions. Therefore, identification and understanding of PTMs in various protein str...

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Bibliographic Details
Published in:Journal of applied crystallography 2020-04, Vol.53 (2), p.569-573
Main Authors: Santhosh, R., Bankoti, Namrata, Gurudarshan, M., Jeyakanthan, J., Sekar, K.
Format: Article
Language:English
Subjects:
Biological activity
Graphical user interface
inserted residues
knowledgebase
modified residues
post‐translational modifications
Protein structure
protein structures
Proteins
Proteomes
Residues
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Summary:Modified residues present in proteins are the result of post‐translational modifications (PTMs). These PTMs increase the functional diversity of the proteome and influence various biological processes and diseased conditions. Therefore, identification and understanding of PTMs in various protein structures is of great significance. In view of this, an online database, Inserted and Modified Residues in Protein Structures (IMRPS), has been developed. IMRPS is a derived database that furnishes information on the residues modified and inserted in the protein structures available in the Protein Data Bank (PDB). The database is equipped with a graphical user interface and has an option to view the data for non‐redundant protein structures (25 and 90%) as well. A quality criteria cutoff has been incorporated to assist in displaying the specific set of PDB codes. The entire protein structure along with the inserted or modified residues can be visualized in JSmol. This database will be updated regularly (presently, every three months) and can be accessed through the URL http://cluster.physics.iisc.ac.in/imrps/. IMRPS is an interactive database for identifying and displaying the inserted and modified residues present in the protein structures available in the Protein Data Bank.
ISSN:1600-5767
0021-8898
1600-5767
DOI:10.1107/S1600576720001880