Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress

The production and secretion of matrix proteins upon stimulation of fibroblasts by transforming growth factor‐beta (TGFβ) play a critical role in wound healing. How TGFβ supports the bioenergetic cost of matrix protein synthesis is not fully understood. Here, we show that TGFβ promotes protein trans...

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Bibliographic Details
Published in:	The EMBO journal 2020-04, Vol.39 (8), p.e103334-n/a
Main Authors:	Schwörer, Simon, Berisa, Mirela, Violante, Sara, Qin, Weige, Zhu, Jiajun, Hendrickson, Ronald C, Cross, Justin R, Thompson, Craig B
Format:	Article
Language:	English
Subjects:	Animals Bioenergetics Biosynthesis Carbon Carbon cycle Catabolism Citric Acid Cycle Collagen Collagen - metabolism Electrode potentials EMBO05 EMBO21 EMBO37 Energy Metabolism Fibroblasts fibrosis Fibrosis - metabolism Glucose Glucose - metabolism Glutamine Glutamine - metabolism Growth factors Humans Matrix protein metabolism Mice Mitochondria Mitochondria - metabolism NIH 3T3 Cells Nutrient utilization Oxidation Oxidation-Reduction Oxidative Phosphorylation Oxidative stress Phosphorylation Proline Proline - metabolism Protein biosynthesis Protein synthesis Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Redox potential Smad4 protein Stimulation TGFβ Transforming Growth Factor beta - metabolism Transforming growth factor-b Translation Tricarboxylic acid cycle Wound healing
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