Recombinant human B cell repertoires enable screening for rare, specific, and natively paired antibodies

The human antibody repertoire is increasingly being recognized as a valuable source of therapeutic grade antibodies. However, methods for mining primary antibody-expressing B cells are limited in their ability to rapidly isolate rare and antigen-specific binders. Here we show the encapsulation of tw...

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Bibliographic Details
Published in:Communications biology 2018-01, Vol.1 (1), p.5, Article 5
Main Authors: Rajan, Saravanan, Kierny, Michael R., Mercer, Andrew, Wu, Jincheng, Tovchigrechko, Andrey, Wu, Herren, Dall′Acqua, William F., Xiao, Xiaodong, Chowdhury, Partha S.
Format: Article
Language:English
Subjects:
631/154/1435/2163
631/154/51/1568
631/61/51/1568
631/61/51/2254
Biology
Biomedical and Life Sciences
Hemagglutinins
Immunoglobulins
Influenza
Life Sciences
Lymphocytes B
Monoclonal antibodies
Next-generation sequencing
Phages
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