NfL and pNfH are increased in Friedreich’s ataxia

Objective To assess neurofilaments as neurodegenerative biomarkers in serum of patients with Friedreich’s ataxia. Methods Single molecule array measurements of neurofilament light (NfL) and heavy chain (pNfH) in 99 patients with genetically confirmed Friedreich’s ataxia. Correlation of NfL/pNfH seru...

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Bibliographic Details
Published in:Journal of neurology 2020-05, Vol.267 (5), p.1420-1430
Main Authors: Hayer, Stefanie Nicole, Liepelt, Inga, Barro, Christian, Wilke, Carlo, Kuhle, Jens, Martus, Peter, Schöls, Ludger
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Ataxia
Biomarkers
Biomarkers - blood
Female
Friedreich Ataxia - blood
Human health and pathology
Humans
Life Sciences
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Neurofilament Proteins - blood
Neurofilaments
Neurology
Neuroradiology
Neurosciences
Original Communication
Serum levels
Young Adult
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