Loading…
Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China
Background: Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on r...
Saved in:
| Published in: | American Journal of Nephrology 2020-05, Vol.51 (5), p.343-348 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Request full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c550t-d83f945bd07094253cbf415b21165bc00e7de30fb7aa10e77ae501dbcbfda0cf3 |
|---|---|
| cites | |
| container_end_page | 348 |
| container_issue | 5 |
| container_start_page | 343 |
| container_title | American Journal of Nephrology |
| container_volume | 51 |
| creator | Wang, Luwen Li, Xun Chen, Hui Yan, Shaonan Li, Dong Li, Yan Gong, Zuojiong |
| description | Background: Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients. Methods: One hundred sixteen COVID-19-confirmed patients enrolled in this study were hospitalized in the Department of Infectious Diseases, Renmin Hospital of Wuhan University from January 14 to February 13, 2020. The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. SARS-CoV-2 RNA in 53 urine sediments of enrolled patients was detected by real-time reverse transcription-polymerase chain reaction. Results: Twelve (10.8%) patients showed mild increase of blood urea nitrogen or creatinine ( |
| doi_str_mv | 10.1159/000507471 |
| format | article |
| fullrecord | <record><control><sourceid>gale_COVID</sourceid><recordid>TN_cdi_proquest_journals_2396370217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A662370311</galeid><sourcerecordid>A662370311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-d83f945bd07094253cbf415b21165bc00e7de30fb7aa10e77ae501dbcbfda0cf3</originalsourceid><addsrcrecordid>eNpt0kFv0zAUB_AIgVg3OHBHyNKkCSQ6np24bjggVR2wwTQQAnG0HOe5dUntYieTypUvjqOOsKIphyj27_0dPb8se0LhlFJevgIADqIQ9F42ogWj43Ii4H42AsZhPIWSH2SHMa4AKJuCeJgd5IyxUuRslP2e--Cdurahi-TMRlQRCS3JhTOoW-sdOfMYyZVvyReMXdMS68hMdy2Sj7Z2uE1y1YXtazJL604122gj8YZQOiHnPm5sqxr7C2vyWbUWXRuJCX5NvndL5V6S-dI69Sh7YFQT8fHN-yj79u7t1_n5-PLT-4v57HKsOYd2XE9zUxa8qkFAWTCe68oUlFcsHcUrDYCixhxMJZSi6UMo5EDrKrFagTb5UfZml7vpqjXWOv1NUI3cBLtWYSu9snJ_x9mlXPhrKagoOStSwPObgOB_dhhbubZRY9Moh76LkuVTzgRLF5Ho8X905buQ-tOrcpILYFT8UwvVoLTO-HSu7kPlbDJhSeW0zzq9Q6WnxrXV3qGxaX2v4ORWwRJV0y6jb7r-PuM-fLGDOvgYA5qhGRRkP1pyGK1kn93u3iD_zlICT3fghwoLDAMY6o_v3J59uNoJualN_gdc39tr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2396370217</pqid></control><display><type>article</type><title>Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China</title><source>Coronavirus Research Database</source><creator>Wang, Luwen ; Li, Xun ; Chen, Hui ; Yan, Shaonan ; Li, Dong ; Li, Yan ; Gong, Zuojiong</creator><creatorcontrib>Wang, Luwen ; Li, Xun ; Chen, Hui ; Yan, Shaonan ; Li, Dong ; Li, Yan ; Gong, Zuojiong</creatorcontrib><description>Background: Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients. Methods: One hundred sixteen COVID-19-confirmed patients enrolled in this study were hospitalized in the Department of Infectious Diseases, Renmin Hospital of Wuhan University from January 14 to February 13, 2020. The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. SARS-CoV-2 RNA in 53 urine sediments of enrolled patients was detected by real-time reverse transcription-polymerase chain reaction. Results: Twelve (10.8%) patients showed mild increase of blood urea nitrogen or creatinine (<26 μmol/L within 48 h), and 8 (7.2%) patients showed trace or 1+ albuminuria in 111 COVID-19-confirmed patients without chronic kidney disease (CKD). All these patients did not meet the diagnostic criteria of AKI. In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. All 5 patients with CKD were survived. Moreover, SARS-CoV-2 RNA in urine sediments was positive only in 3 patients from 48 cases without CKD, and 1 patient had a positive for SARS-CoV-2 open reading frame 1ab from 5 cases with CKD. Conclusion: AKI was uncommon in COVID-19. SARS-CoV-2 infection does not result in AKI, or aggravate CKD in the COVID-19 patients.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000507471</identifier><identifier>PMID: 32229732</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acute Disease ; Acute renal failure ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; China - epidemiology ; Coronavirus Infections - mortality ; COVID-19 ; Demographic aspects ; Female ; Hospitalization ; Humans ; Kidney Diseases ; Kidney Function Tests ; Male ; Middle Aged ; Pandemics ; Patient-Oriented, Translational Research ; Patient-Oriented, Translational Research: Research Article ; Pneumonia, Viral - mortality ; Risk factors ; SARS-CoV-2 ; Young Adult</subject><ispartof>American Journal of Nephrology, 2020-05, Vol.51 (5), p.343-348</ispartof><rights>2020 S. Karger AG, Basel</rights><rights>2020 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2020 S. Karger AG</rights><rights>2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.karger.com/Tap/Home/278492 Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-d83f945bd07094253cbf415b21165bc00e7de30fb7aa10e77ae501dbcbfda0cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2396370217?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>780,784,885,27924,38515,43894</link.rule.ids><linktorsrc>$$Uhttps://www.proquest.com/docview/2396370217?pq-origsite=primo$$EView_record_in_ProQuest$$FView_record_in_$$GProQuest</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32229732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Luwen</creatorcontrib><creatorcontrib>Li, Xun</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Yan, Shaonan</creatorcontrib><creatorcontrib>Li, Dong</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Gong, Zuojiong</creatorcontrib><title>Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China</title><title>American Journal of Nephrology</title><addtitle>Am J Nephrol</addtitle><description>Background: Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients. Methods: One hundred sixteen COVID-19-confirmed patients enrolled in this study were hospitalized in the Department of Infectious Diseases, Renmin Hospital of Wuhan University from January 14 to February 13, 2020. The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. SARS-CoV-2 RNA in 53 urine sediments of enrolled patients was detected by real-time reverse transcription-polymerase chain reaction. Results: Twelve (10.8%) patients showed mild increase of blood urea nitrogen or creatinine (<26 μmol/L within 48 h), and 8 (7.2%) patients showed trace or 1+ albuminuria in 111 COVID-19-confirmed patients without chronic kidney disease (CKD). All these patients did not meet the diagnostic criteria of AKI. In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. All 5 patients with CKD were survived. Moreover, SARS-CoV-2 RNA in urine sediments was positive only in 3 patients from 48 cases without CKD, and 1 patient had a positive for SARS-CoV-2 open reading frame 1ab from 5 cases with CKD. Conclusion: AKI was uncommon in COVID-19. SARS-CoV-2 infection does not result in AKI, or aggravate CKD in the COVID-19 patients.</description><subject>Acute Disease</subject><subject>Acute renal failure</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Betacoronavirus</subject><subject>China - epidemiology</subject><subject>Coronavirus Infections - mortality</subject><subject>COVID-19</subject><subject>Demographic aspects</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Kidney Diseases</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Patient-Oriented, Translational Research</subject><subject>Patient-Oriented, Translational Research: Research Article</subject><subject>Pneumonia, Viral - mortality</subject><subject>Risk factors</subject><subject>SARS-CoV-2</subject><subject>Young Adult</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><recordid>eNpt0kFv0zAUB_AIgVg3OHBHyNKkCSQ6np24bjggVR2wwTQQAnG0HOe5dUntYieTypUvjqOOsKIphyj27_0dPb8se0LhlFJevgIADqIQ9F42ogWj43Ii4H42AsZhPIWSH2SHMa4AKJuCeJgd5IyxUuRslP2e--Cdurahi-TMRlQRCS3JhTOoW-sdOfMYyZVvyReMXdMS68hMdy2Sj7Z2uE1y1YXtazJL604122gj8YZQOiHnPm5sqxr7C2vyWbUWXRuJCX5NvndL5V6S-dI69Sh7YFQT8fHN-yj79u7t1_n5-PLT-4v57HKsOYd2XE9zUxa8qkFAWTCe68oUlFcsHcUrDYCixhxMJZSi6UMo5EDrKrFagTb5UfZml7vpqjXWOv1NUI3cBLtWYSu9snJ_x9mlXPhrKagoOStSwPObgOB_dhhbubZRY9Moh76LkuVTzgRLF5Ho8X905buQ-tOrcpILYFT8UwvVoLTO-HSu7kPlbDJhSeW0zzq9Q6WnxrXV3qGxaX2v4ORWwRJV0y6jb7r-PuM-fLGDOvgYA5qhGRRkP1pyGK1kn93u3iD_zlICT3fghwoLDAMY6o_v3J59uNoJualN_gdc39tr</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Wang, Luwen</creator><creator>Li, Xun</creator><creator>Chen, Hui</creator><creator>Yan, Shaonan</creator><creator>Li, Dong</creator><creator>Li, Yan</creator><creator>Gong, Zuojiong</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>COVID</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200501</creationdate><title>Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China</title><author>Wang, Luwen ; Li, Xun ; Chen, Hui ; Yan, Shaonan ; Li, Dong ; Li, Yan ; Gong, Zuojiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-d83f945bd07094253cbf415b21165bc00e7de30fb7aa10e77ae501dbcbfda0cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Disease</topic><topic>Acute renal failure</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Betacoronavirus</topic><topic>China - epidemiology</topic><topic>Coronavirus Infections - mortality</topic><topic>COVID-19</topic><topic>Demographic aspects</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Kidney Diseases</topic><topic>Kidney Function Tests</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pandemics</topic><topic>Patient-Oriented, Translational Research</topic><topic>Patient-Oriented, Translational Research: Research Article</topic><topic>Pneumonia, Viral - mortality</topic><topic>Risk factors</topic><topic>SARS-CoV-2</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Luwen</creatorcontrib><creatorcontrib>Li, Xun</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Yan, Shaonan</creatorcontrib><creatorcontrib>Li, Dong</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Gong, Zuojiong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Coronavirus Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American Journal of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wang, Luwen</au><au>Li, Xun</au><au>Chen, Hui</au><au>Yan, Shaonan</au><au>Li, Dong</au><au>Li, Yan</au><au>Gong, Zuojiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China</atitle><jtitle>American Journal of Nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>51</volume><issue>5</issue><spage>343</spage><epage>348</epage><pages>343-348</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><abstract>Background: Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients. Methods: One hundred sixteen COVID-19-confirmed patients enrolled in this study were hospitalized in the Department of Infectious Diseases, Renmin Hospital of Wuhan University from January 14 to February 13, 2020. The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. SARS-CoV-2 RNA in 53 urine sediments of enrolled patients was detected by real-time reverse transcription-polymerase chain reaction. Results: Twelve (10.8%) patients showed mild increase of blood urea nitrogen or creatinine (<26 μmol/L within 48 h), and 8 (7.2%) patients showed trace or 1+ albuminuria in 111 COVID-19-confirmed patients without chronic kidney disease (CKD). All these patients did not meet the diagnostic criteria of AKI. In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. All 5 patients with CKD were survived. Moreover, SARS-CoV-2 RNA in urine sediments was positive only in 3 patients from 48 cases without CKD, and 1 patient had a positive for SARS-CoV-2 open reading frame 1ab from 5 cases with CKD. Conclusion: AKI was uncommon in COVID-19. SARS-CoV-2 infection does not result in AKI, or aggravate CKD in the COVID-19 patients.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>32229732</pmid><doi>10.1159/000507471</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0250-8095 |
| ispartof | American Journal of Nephrology, 2020-05, Vol.51 (5), p.343-348 |
| issn | 0250-8095 1421-9670 |
| language | eng |
| recordid | cdi_proquest_journals_2396370217 |
| source | Coronavirus Research Database |
| subjects | Acute Disease Acute renal failure Adult Aged Aged, 80 and over Betacoronavirus China - epidemiology Coronavirus Infections - mortality COVID-19 Demographic aspects Female Hospitalization Humans Kidney Diseases Kidney Function Tests Male Middle Aged Pandemics Patient-Oriented, Translational Research Patient-Oriented, Translational Research: Research Article Pneumonia, Viral - mortality Risk factors SARS-CoV-2 Young Adult |
| title | Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T01%3A52%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_COVID&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coronavirus%20Disease%2019%20Infection%20Does%20Not%20Result%20in%20Acute%20Kidney%20Injury:%20An%20Analysis%20of%20116%20Hospitalized%20Patients%20from%20Wuhan,%20China&rft.jtitle=American%20Journal%20of%20Nephrology&rft.au=Wang,%20Luwen&rft.date=2020-05-01&rft.volume=51&rft.issue=5&rft.spage=343&rft.epage=348&rft.pages=343-348&rft.issn=0250-8095&rft.eissn=1421-9670&rft_id=info:doi/10.1159/000507471&rft_dat=%3Cgale_COVID%3EA662370311%3C/gale_COVID%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c550t-d83f945bd07094253cbf415b21165bc00e7de30fb7aa10e77ae501dbcbfda0cf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2396370217&rft_id=info:pmid/32229732&rft_galeid=A662370311&rfr_iscdi=true |