Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,...

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Bibliographic Details
Published in:Medicinal chemistry research 2020-06, Vol.29 (6), p.935-941
Main Authors: Patel, Hinal, Mothia, Begum, Patel, Jaison, Fasanya, Olatunde, Sooda, Kartheek, Javid, Farideh, Wyatt, Peter B.
Format: Article
Language:English
Subjects:
Aldehydes
Aliphatic compounds
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Cisplatin
Cytotoxicity
Hydroxybenzaldehydes
Ketones
Original Research
Ovarian cancer
Ovarian carcinoma
Pharmacology/Toxicology
Toxicity
Vanillin
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Summary:Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-020-02532-5