Do SARS-CoV2 Viral Proteins have Neuromodulatory Properties?

[2] One school of thought suggests that neurotropism is a common finding for CoVs. [...]it is warranted to know if SARS-CoV-2 can affect the central nervous system (CNS), causing neuronal injury resulting in acute respiratory distress along with other neurological deficits. [9] Two proteins, the spi...

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Published in:Neurology India 2020-03, Vol.68 (2), p.274-275
Main Authors: Banerjee, Jyotirmoy, Tripathi, Manjari, Chandra, P, Dixit, Aparna
Format: Article
Language:English
Subjects:
Bronchitis
Coronavirus infections
Coronaviruses
COVID-19
Disease transmission
Diseases
Genomes
Health aspects
Infections
Middle East respiratory syndrome
Novels
Pneumonia
Proteins
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Viral proteins
Viruses
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Summary:[2] One school of thought suggests that neurotropism is a common finding for CoVs. [...]it is warranted to know if SARS-CoV-2 can affect the central nervous system (CNS), causing neuronal injury resulting in acute respiratory distress along with other neurological deficits. [9] Two proteins, the spike protein (S) and main protease Nsp5 are potential molecules as a prominent number of interactions were related to lipid modifications and vesicle trafficking to S protein whereas Nsp5 showed high confidence interaction with the epigenetic regulator histone deacetylase 2 (HDAC2). [...]strategies could be (1) detailed neurological investigations and isolation of SARS-CoV-2 from different regions of the brain such as cerebrospinal fluid, glial cells, neuronal tissue and blood samples of autopsies of the COVID-19 patients (2) Host-virus interaction studies using either omics approach (genomic/transcriptomic/proteomic/lipidomic/metabolomic) or cloning and expressing individual COVID-19 proteins in different neuronal cell lines followed by pull-down assays and mass spectrometry and analyzing the interacting protein network.
ISSN:0028-3886
1998-4022
DOI:10.4103/0028-3886.283760