Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis

IMPORTANCE: The benefit of blood pressure lowering for the prevention of dementia or cognitive impairment is unclear. OBJECTIVE: To determine the association of blood pressure lowering with dementia or cognitive impairment. DATA SOURCES AND STUDY SELECTION: Search of PubMed, EMBASE, and CENTRAL for...

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Bibliographic Details
Published in:	JAMA : the journal of the American Medical Association 2020-05, Vol.323 (19), p.1934-1944
Main Authors:	Hughes, Diarmaid, Judge, Conor, Murphy, Robert, Loughlin, Elaine, Costello, Maria, Whiteley, William, Bosch, Jackie, O’Donnell, Martin J, Canavan, Michelle
Format:	Article
Language:	English
Subjects:	Aged Antihypertensive Agents - therapeutic use Antihypertensives Blood pressure Blood Pressure - drug effects Clinical trials Cognitive ability Cognitive Dysfunction - epidemiology Cognitive Dysfunction - prevention & control Dementia Dementia - epidemiology Dementia - prevention & control Dementia disorders Female Follow-Up Studies Humans Hypertension - complications Hypertension - drug therapy Impairment Male Meta-analysis Original Investigation Randomization Randomized Controlled Trials as Topic Risk Risk management Risk reduction Systematic review
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