Auto‐Oxidative Povarov/Aromatization Tandem Reaction of Glycine Derivatives with Enamides: Acylamino as both Activating and Leaving Group

The auto‐oxidative Povarov/aromatization tandem reaction of N‐aryl glycine derivatives with enamides yields a series of complex quinoline derivatives in good yields. The reactions are performed using only catalytic amount of Brønsted acid and O2. The acylamino group is used as both activating and le...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2020-06, Vol.9 (6), p.925-928
Main Authors: Huang, Songhai, Bao, Xiazhen, Fu, Ying, Zhang, Yongxin, Quan, Zhengjun, Huo, Congde
Format: Article
Language:English
Subjects:
Aromatic compounds
auto-oxidation
Cascade chemical reactions
Derivatives
enamides
Glycine
glycine derivatives
Organic chemistry
Quinoline
quinolines
tandem reaction
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Summary:The auto‐oxidative Povarov/aromatization tandem reaction of N‐aryl glycine derivatives with enamides yields a series of complex quinoline derivatives in good yields. The reactions are performed using only catalytic amount of Brønsted acid and O2. The acylamino group is used as both activating and leaving group to improve the reaction efficiency in this transformation. Cyclization: Auto‐oxidative Povarov/aromatization tandem reaction of N‐aryl glycine derivatives with enamides yields a series of complex quinoline derivatives in good yields. The reactions are performed using only catalytic amount of Brønsted acid and O2. The acylamino group is used as both activating and leaving group to improve the reaction efficiency in this transformation
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202000191