Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project

Telomere length (TL) is a marker of biological age that may be affected by dietary factors through oxidation and inflammation mechanisms. In addition, ultra-processed food (UPF) consumption has increased worldwide and it has been associated with the risk of developing several diseases. We aimed to e...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2020-06, Vol.111 (6), p.1259-1266
Main Authors: Alonso-Pedrero, Lucia, Ojeda-Rodríguez, Ana, Martínez-González, Miguel A, Zalba, Guillermo, Bes-Rastrollo, Maira, Marti, Amelia
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - metabolism
Cross-Sectional Studies
diet
Energy consumption
Evaluation
Fast Foods - adverse effects
Female
Follow-Up Studies
Food
Food consumption
Food processing
Geriatrics
Humans
Male
Middle Aged
Older people
Oxidation
Processed foods
Prospective Studies
Quartiles
Regression analysis
Regression models
Risk
Saliva
Spain
SUN cohort
Telomerase
Telomere - genetics
Telomere - metabolism
telomere length
Telomere Shortening
Telomeres
ultra-processed food
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Summary:Telomere length (TL) is a marker of biological age that may be affected by dietary factors through oxidation and inflammation mechanisms. In addition, ultra-processed food (UPF) consumption has increased worldwide and it has been associated with the risk of developing several diseases. We aimed to evaluate the association between UPF consumption and the risk of having short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project. This is a cross-sectional study of 886 participants (645 men and 241 women) aged 57–91 y recruited from the SUN Project (Spain, 1999–2018). TL was measured from saliva samples by real-time qPCR at baseline and UPF consumption was collected using a validated 136-item FFQ and classified according to the NOVA system. We evaluated the association between consumption of energy-adjusted UPF categorized into quartiles (low, medium-low, medium-high, and high consumption) and the risk of having short telomeres (3 servings/d) was associated with higher risk of having shorter telomeres in an elderly Spanish population of the SUN Project. This trial was registered at clinicaltrials.gov as NCT02669602.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/nqaa075