Reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide

The reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide in ethanol as solvent produces 4-[(alkylsulfanyl)- methyl]-substituted 1-(pyridin-3-yl)carbonyl-1 H -pyrazoles, whereas 1-acyl-1 H -pyrazoles are formed in acetic, propanoic, or pentanoic acid solution. The reaction...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-05, Vol.56 (5), p.548-554
Main Authors: Baeva, Larisa A., Nugumanov, Radik M., Gataullin, Rail R., Fatykhov, Akhnef А.
Format: Article
Language:English
Subjects:
Antagonists
Carbonyls
Chemistry
Chemistry and Materials Science
Ethanol
Niacin
Nicotinic acid
Organic Chemistry
Pharmacy
Progesterone
Substitutes
Zinc chloride
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide in ethanol as solvent produces 4-[(alkylsulfanyl)- methyl]-substituted 1-(pyridin-3-yl)carbonyl-1 H -pyrazoles, whereas 1-acyl-1 H -pyrazoles are formed in acetic, propanoic, or pentanoic acid solution. The reaction in methanol in the presence of ZnCl 2 is accompanied by elimination of nicotinic acid and the formation of (alkylsulfanyl)methyl-substituted 1 H -pyrazoles.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-020-02698-1