Maackiain Ameliorates 6-Hydroxydopamine and SNCA Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson’s Disease in Caenorhabditis elegans and the SH-SY5Y Cell Line

The movement disorder Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease, and is associated with aging, the environment, and genetic factors. The intracellular aggregation of α-synuclein and the loss of dopaminergic neurons in the substantia nigra pars compact...

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Bibliographic Details
Published in:	International journal of molecular sciences 2020-06, Vol.21 (12), p.4455
Main Authors:	Tsai, Rong-Tzong, Tsai, Chia-Wen, Liu, Shih-Ping, Gao, Jia-Xin, Kuo, Yun-Hua, Chao, Pei-Min, Hung, Huey-Shan, Shyu, Woei-Cherng, Lin, Shinn-Zong, Fu, Ru-Huei
Format:	Article
Language:	English
Subjects:	Adrenergic Agents - toxicity alpha-Synuclein - toxicity Animals Apoptosis Autophagy Caenorhabditis elegans - drug effects Caenorhabditis elegans - growth & development Disease Models, Animal Food Gene Expression Regulation - drug effects Humans Kinases Mitochondria Mutation Nematodes Neuroblastoma - drug therapy Neuroblastoma - etiology Neuroblastoma - pathology Neurons Oxidative stress Oxidopamine - toxicity Parkinson Disease - drug therapy Parkinson Disease - etiology Parkinson Disease - pathology Parkinson's disease Protein Kinases - genetics Protein Kinases - metabolism Proteins Pterocarpans - pharmacology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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