A comparative assessment of poly(vinylidene fluoride)/conducting polymer electrospun nanofiber membranes for biomedical applications

Piezoelectric polymers, especially poly(vinylidene fluoride) (PVDF) are increasingly receiving interest as smart biomaterials for tissue engineering, energy harvesting, microfluidic, actuator, and biosensor applications. Despite possessing the greatest piezoelectric coefficients among all piezoelect...

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Bibliographic Details
Published in:Journal of applied polymer science 2020-10, Vol.137 (37), p.n/a
Main Authors: Sengupta, Pavel, Ghosh, Aritri, Bose, Navonil, Mukherjee, Sampad, Roy Chowdhury, Amit, Datta, Pallab
Format: Article
Language:English
Subjects:
Actuators
Biocompatibility
biomaterials
Biomedical materials
Biosensors
Biotechnology
blends
Conducting polymers
Electrical resistivity
Energy harvesting
Energy storage
Fluorides
Glutamic acid
Materials science
Materials selection
Membranes
Microfluidics
Nanofibers
Piezoelectricity
Polyanilines
Polymer matrix composites
Polymers
Polypyrroles
Polyvinylidene fluorides
Tissue engineering
Vinylidene fluoride
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Summary:Piezoelectric polymers, especially poly(vinylidene fluoride) (PVDF) are increasingly receiving interest as smart biomaterials for tissue engineering, energy harvesting, microfluidic, actuator, and biosensor applications. Despite possessing the greatest piezoelectric coefficients among all piezoelectric polymers, it is often desirable to increase the electrical outputs from PVDF for several of these applications. Blending with intrinsically conducting polymers (CP) in the form of nanofiber membranes is one of the facile methods to achieve the same. However, these polymers and their composites have so far been primarily investigated only for their physical property enhancements and in applications like energy storage while their biomedical applications and comparative assessment of their biocompatibility properties have not been yet explored. In this report, electrospinning of PVDF blends with polypyrrole (PPy), polyaniline (PANI), and a modified PANI with l‐glutamic acid (PANI‐LGA/P‐LGA) is performed to obtain different electrically active material membranes. The PVDF:CP composite nanofibers are compared with respect to their nanostructures, β‐phase content, and electrical conductivity. Further, biocompatibility of all the membranes was compared. It was found that incorporation of PPy, PANI, and P‐LGA increased the electrical conductivity of PVDF while the β‐phase content was also substantially enhanced. The highest biocompatibility with a pre‐osteoblast cell line (MC3T3) was exhibited in the order p‐LGA/PVDF > PANI/PVDF > PPy/PVDF, all being significantly higher than PVDF (p 
ISSN:0021-8995
1097-4628
DOI:10.1002/app.49115