Tandem Phospha‐Michael Addition/N‐Acylation/ Intramolecular Wittig Reaction of aza‐o‐Quinone Methides: Approaches to 2,3‐Disubstituted Indoles

A tandem phospha‐Michael addition/N‐acylation/intramolecular Wittig reaction of in situ formed aza‐o‐QMs is disclosed. This approach features high functional group tolerance and provides a convenient and practical access to biologically significant indole derivatives (37 examples, up to 91% yield) u...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-07, Vol.362 (13), p.2615-2619
Main Authors: Hua, Ting‐Bi, Chao, Fei, Wang, Long, Yan, Chen‐Yang, Xiao, Cong, Yang, Qing‐Qing, Xiao, Wen‐Jing
Format: Article
Language:English
Subjects:
Acylation
aza-o-Quinone Methides
Functional groups
Indoles
Intramolecular Wittig Reaction
Phospha-Michael Addition
Quinones
Tandem Reaction
Ιndoles
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Summary:A tandem phospha‐Michael addition/N‐acylation/intramolecular Wittig reaction of in situ formed aza‐o‐QMs is disclosed. This approach features high functional group tolerance and provides a convenient and practical access to biologically significant indole derivatives (37 examples, up to 91% yield) under mild reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000343