Unit-Dose Packaging and Unintentional Buprenorphine-Naloxone Exposures

Buprenorphine accounts for the most opioid-related pediatric hospital admissions when compared with other opioid analgesics. Since 2010, several manufacturers began distributing their buprenorphine products with unit-dose packaging (UDP). Our main objective in this study is to evaluate the impact of...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2018-06, Vol.141 (6), p.1
Main Authors: Wang, George Sam, Severtson, S Geoffrey, Bau, Gabrielle E, Dart, Richard C, Green, Jody L
Format: Article
Language:English
Subjects:
Abuse
Addictions
Analgesics
Analysis
Buprenorphine
Children
Combination drug therapy
Dosage and administration
Dose-response relationship
Dose-response relationship (Biochemistry)
Drug therapy, Combination
Exposure
Mental depression
Naloxone
Narcotics
Opioids
Packaging
Pediatric nursing
Pediatrics
Prescriptions
Substance abuse treatment
Surveillance
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Summary:Buprenorphine accounts for the most opioid-related pediatric hospital admissions when compared with other opioid analgesics. Since 2010, several manufacturers began distributing their buprenorphine products with unit-dose packaging (UDP). Our main objective in this study is to evaluate the impact of UDP on unintentional pediatric buprenorphine-naloxone poison center exposures. This is an observational surveillance study in which the Researched Abuse, Diversion, and Addiction-Related Surveillance System Poison Center Program is used. The main outcome was cases of unintentional ingestions involving children
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2017-4232