The stimuli-responsive properties of doxorubicin adsorbed onto bimetallic Au@Pd nanodendrites and its potential application as drug delivery platform

• Published in: Materials Science & Engineering C 2020-05, Vol.110, p.110696, Article 110696
• Main Authors: Oladipo, Adewale O., Nkambule, Thabo T.I., Mamba, Bhekie B., Msagati, Titus A.M.
• Format: Article
• Language: English
• Subjects: Adsorption; Adsorption - drug effects; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bimetallic nanodendrites; Bimetals; Binding; Computer simulation; Dendritic Cells - drug effects; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Carriers - chemistry; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Drug interaction; Drug interactions; Drug release; Gold; Gold - chemistry; Humans; Isotherms; Kinetics; Materials science; Metal Nanoparticles - chemistry; Nanoparticles; Nanostructures - chemistry; Palladium; PEGylation; Polarity; Polyethylene glycol; Polyethylene Glycols - chemistry; Stimuli; Sulfhydryl Compounds - chemistry; Time dependence; Tumor Microenvironment - drug effects
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2020.110696

Bimetallic nanoparticles have continued to attract interest as drug delivery systems in cancer therapy even though their nature of interaction with small molecules is limited. Currently, many delivery systems based on monometallic nanoparticles are being fabricated for loading of drugs, thus prompting the need to explore and get more understanding of dendritic bimetallic nanostructure-drug interaction. The bimetallic gold-core palladium-dendritic shell nanoparticles (Au@PdNDs) were synthesized by hot injection method and stabilized with methoxy polyethylene glycol thiol (mPEG-SH). An anti-cancer drug, doxorubicin (DOX) was conjugated to the bimetallic nanodendrites leading to the formation of DOX/[e-mail] complex. We used TEM, FTIR, and zeta-potential to study the drug-nanodendrites interaction. The effect of DOX binding and release capacity with regards to pH, adsorption kinetics, solvent polarity, isotherms and temperature on [e-mail] were investigated. The results showed a spontaneous heterogeneous binding of DOX on the [e-mail] surfaces and time-dependent loading capacity of ~90% maximum adsorption within 24 h. Moreover, the experimental results showed that the adsorption isotherm data fitted well with the Freundlich model and a pseudo-second order adsorption kinetics. The desorption of DOX was triggered under simulated tumor microenvironmental conditions and should open new opportunities for potential multi stimuli-responsive drug delivery applications. Schematic illustration showing the adsorption of doxorubicin onto PEGylated Au@PdNDs. [Display omitted] •Bimetallic gold-core palladium nanodendrites (Au@PdNDs) was synthesized by hot injection method.•PEGylated Au@PdNDs showed rapid but time-dependent doxorubicin (DOX) adsorption.•The [e-mail] showed maximum loading capacity of ~90% at 24 h.•Adsorption data indicated a Freundlich isotherm model and pseudo-second order kinetics.•The DOX-loaded [e-mail] showed pH, temperature, solvent, enzyme triggered desorption of DOX.