Synthesis and evaluation of novel 1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazole tethered chalcone hybrids as potential anticancer agents

A series of novel 1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazole tethered chalcone derivatives were designed synthesized by using conventional as well as microwave assisted methods and characterized by 1H NMR, 13C NMR and mass spectral analysis. Microwave assisted synthesis caused an improvement in yield...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2020-09, Vol.57 (9), p.3318-3325
Main Authors: Bujji, Sushmitha, Edigi, Praveen Kumar, Subhashini, Naikal James Prameela
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Colon
Derivatives
NMR
Nuclear magnetic resonance
Reaction time
Spectrum analysis
Thiadiazoles
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Summary:A series of novel 1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazole tethered chalcone derivatives were designed synthesized by using conventional as well as microwave assisted methods and characterized by 1H NMR, 13C NMR and mass spectral analysis. Microwave assisted synthesis caused an improvement in yield and significant reduction in the reaction time of all the derivatives. All the new synthesized derivatives were further evaluated for their anti‐cancer activity against selected four human cancer cell lines; A549 (Lung), MCF‐7 (Breast), Colo‐205 (Colon) and A2780 (Ovarian). Among the synthesized compounds, 7b, 7c, 7d, 7e, 7g and 7h exhibited potent anticancer activity compared to control drug (etoposide).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4047