Printed Electroceutical Dressings for the Inhibition of Biofilms and Treatment of Chronic Wounds

We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxyge...

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Bibliographic Details
Published in:Journal of microelectromechanical systems 2020-10, Vol.29 (5), p.918-923
Main Authors: Heald, Rachel, Bennett, Molly, Subramaniam, Vish V., Dusane, Devendra, Lochab, Varun, Sundaram, Prashanth Mohana, Salyer, Sarah, West, J. D., Stoodley, Paul, Prakash, Shaurya
Format: Article
Language:English
Subjects:
Anodes
Bacteria
biofilm
Biofilms
Biomarkers
Biomedical imaging
Bluetooth
chronic
Circuits
dressing
Electric potential
Electroceuticals
Microorganisms
Remote monitoring
Soft tissues
treatment
wound
Wound healing
Wounds
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Summary:We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both Gram-positive and Gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth ® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth ® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds. [2020-0129]
ISSN:1057-7157
1941-0158
DOI:10.1109/JMEMS.2020.2999260