Synthesis and Cytotoxic Activity of New1,4-Dithiazolyl-5-oxopyrrole Derivatives, Their 1,2,4-Triazoles and NucleosideAnalogs

New 1,4-bithiazolyl-5-oxopyrrole derivatives have been synthesized via a multicomponent reaction (MCR) and their structures characterized. N1-Phenyl- and N1-amino-substituted 1,2,4-triazole derivatives linked with bithiazolyl-5-oxopyrrole system also have been synthesized. Glycosylation of the latte...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of general chemistry 2020-01, Vol.90 (8), p.1544-1552
Main Authors: Tolan H E M, Radwan M A A, Khalaf, H S, El-Bayaa, M N, Awad, H M, El-Sayed, W A
Format: Article
Language:English
Subjects:
Animal behavior
Cancer
Colon
Cytotoxicity
Derivatives
Doxorubicin
Halides
Triazoles
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:New 1,4-bithiazolyl-5-oxopyrrole derivatives have been synthesized via a multicomponent reaction (MCR) and their structures characterized. N1-Phenyl- and N1-amino-substituted 1,2,4-triazole derivatives linked with bithiazolyl-5-oxopyrrole system also have been synthesized. Glycosylation of the latter s-triazole compounds by acetylated glycosyl halides has led to the corresponding thioglycoside derivatives. Cytotoxic activity data of the synthesized compounds against colon (HCT-116) and breast (MCF-7) human cancer sells determined by the MTT assay indicate two 1,2,4-triazole thioglycosides as potentially active in comparison with doxorubicin against MCF-7 cancer.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220080241