Novel synthetic approach to pyrrolo[1,2-b]cinnolines

Straightforward method for the synthesis of pyrrolo[1,2- b ]cinnolines starting from 2-nitrobenzaldehydes and 2-methylfurans has been elaborated. The key steps of the process are oxidative furan ring opening with diazonium cation and intramolecular alkylation of azo group of the resulted cinnoline w...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-08, Vol.56 (8), p.1030-1041
Main Authors: Plieva, Anastasia T., Chalikidi, Petrakis N., Gutnov, Andrey V., Turiev, Anatolij M., Demidov, Oleg P., Aksenov, Nicolai A., Magkoev, Taimuraz T., Abaev, Vladimir T.
Format: Article
Language:English
Subjects:
Alkylation
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pharmacy
Ring opening
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Summary:Straightforward method for the synthesis of pyrrolo[1,2- b ]cinnolines starting from 2-nitrobenzaldehydes and 2-methylfurans has been elaborated. The key steps of the process are oxidative furan ring opening with diazonium cation and intramolecular alkylation of azo group of the resulted cinnoline with secondary allyl alcohol.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-020-02770-w