Totally atom-economical synthesis of lactic acid from formaldehyde: combined bio-carboligation and chemo-rearrangement without the isolation of intermediates

Non-fermentative chemoenzymatic transformations have attracted great interest from both academia and industry. Here, we report a green chemoenzymatic cascade reaction that converts the C1 compound formaldehyde into lactic acid using a newly identified formolase variant and NaOH as catalysts with 100...

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Bibliographic Details
Published in:	Green chemistry : an international journal and green chemistry resource : GC 2020-10, Vol.22 (2), p.689-6814
Main Authors:	Li, Tianzhen, Tang, Zijing, Wei, Hongli, Tan, Zijian, Liu, Pi, Li, Jinlong, Zheng, Yingying, Lin, Jianping, Liu, Weidong, Jiang, Huifeng, Liu, Haifeng, Zhu, Leilei, Ma, Yanhe
Format:	Article
Language:	English
Subjects:	Amino acids Atom economy Carbon Cascade chemical reactions Catalysts Crystal structure Dihydroxyacetone Formaldehyde Glycolaldehyde Green chemistry industry Intermediates Lactic acid mechanics Molecular dynamics Sodium hydroxide surface area
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