Seroprevalence of Crimean‐Congo haemorrhagic fever among three selected risk human groups in disease‐endemic region of Pakistan

The occurrence of Crimean‐Congo haemorrhagic fever (CCHF) in humans is linked with animals living in close vicinity, and information on the incidence of CCHF at the human–animal interface is scarce. Therefore, the current study was designed to identify the high‐risk groups of individuals linked with...

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Bibliographic Details
Published in:Zoonoses and public health 2020-11, Vol.67 (7), p.755-759
Main Authors: Shahid, Muhammad Furqan, Shabbir, Muhammad Zubair, Ashraf, Kamran, Ali, Muzaffar, Yaqub, Saima, Mukhtar, Nadia, Zafar Khan, Adnan, Tahir, Zarfishan, Yaqub, Tahir
Format: Article
Language:English
Subjects:
Abattoirs
Adolescent
Adult
Animal Husbandry
Animals
Antibodies
Chakwal
Crimean hemorrhagic fever
Crimean‐Congo haemorrhagic fever
Dairying
Disease control
Factor analysis
Female
Fever
Haemorrhage
Handlers
Health risks
Hemorrhagic Fever, Crimean - epidemiology
Humans
Immunoglobulin G
Male
Middle Aged
Occupational Exposure
Pakistan - epidemiology
Risk analysis
Risk Factors
Risk groups
Seroepidemiologic Studies
Serology
seroprevalence
Surveillance
Young Adult
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Summary:The occurrence of Crimean‐Congo haemorrhagic fever (CCHF) in humans is linked with animals living in close vicinity, and information on the incidence of CCHF at the human–animal interface is scarce. Therefore, the current study was designed to identify the high‐risk groups of individuals linked with animals in the Chakwal district of Pakistan having a history of CCHF cases in humans. In subject matter, coupled with risk factor analysis, we performed a sero‐based CCHF surveillance in three selected risk groups of humans including abattoir workers (n = 137), milkmen (n = 169) and animal handlers (n = 147). Sera samples and questionnaire‐based data were collected from each of the participants and screened for anti‐CCHFV IgG antibodies using enzyme‐linked immunosorbent assay. The highest seroprevalence was observed in animal handlers (n = 14, 9.52%, 95% CI: 4.68–13.99) followed by abattoir workers (n = 9, 6.57%, 95% CI: 2.42–10.72) and milkmen (n = 3, 1.78%, 95% CI: 0.24–4.24). The risk of seropositivity was significantly associated with humans linked with tick‐infested animals (OR: 11.0, 95% CI: 1.5–83.0, p = .002), old age >40 years (OR: 6.6, 95% CI: 2.7–16.0, p 
ISSN:1863-1959
1863-2378
DOI:10.1111/zph.12704