Palladium‐catalyzed cross‐coupling reactions of coumarin derivatives: An overview

Coumarins are omnipresent in several plants and exhibit a plethora of pharmacological properties, making them an important scaffold in organic synthesis. Naturally, the chemistry of this motif has attracted ever‐increasing attention, among which palladium‐catalyzed coupling reactions are the most pr...

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Bibliographic Details
Published in:Applied organometallic chemistry 2020-12, Vol.34 (12), p.n/a
Main Authors: Kanchana, U.S., Diana, Elizabeth J., Mathew, Thomas V., Anilkumar, Gopinathan
Format: Article
Language:English
Subjects:
catalysis
Chemical reactions
Chemical synthesis
Chemistry
Coumarin
Cross coupling
C–C
Derivatives
Palladium
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Summary:Coumarins are omnipresent in several plants and exhibit a plethora of pharmacological properties, making them an important scaffold in organic synthesis. Naturally, the chemistry of this motif has attracted ever‐increasing attention, among which palladium‐catalyzed coupling reactions are the most prevalent one. Numerous useful, easy, and concise syntheses and reactions have been achieved using palladium‐catalyzed coupling reactions. This review focuses on recent advances in palladium‐catalyzed cross‐coupling reactions such as Suzuki, Heck, Stille, Sonogoshira etc. reactions of coumarin derivatives and covers the literature from 2001 to 2020. Coumarins generally have a broad range of biological activities which varies with its structure. Even though coumarins with different substituents at C‐3, C‐4 and C‐7 are explored using various reaction types, the positions C‐5, C‐6 and C‐8 remain relatively unexplored. Hence, there is a significant scope in this type of cross‐coupling reactions in coumarin chemistry for the development of functionalized and structurally diverse novel coumarin derivatives through placement of appropriate functional groups around the coumarin nucleus at different positions, which may be of potential biological interest.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.5983