Catalyst and Additive‐Free Direct Amidation/Halogenation of Tertiary Arylamines with N‐haloimide/amides

An approach has been developed for the amidation (halogenation) of tertiary arylamines by electrophilic activation using N‐haloimide/amides. Several control experiments have been performed, and the coupling reaction outcomes indicated that the N‐haloimide/amide brings three major functions, includin...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-11, Vol.362 (22), p.5002-5008
Main Authors: Xu, Xiu‐Juan, Amuti, Adila, Wusiman, Abudureheman
Format: Article
Language:English
Subjects:
Additives
amidation
Amides
Amines
Cascade chemical reactions
catalyst-free
Catalysts
C−H activation
Halogenation
N-haloimide
Nitrogen
Organic compounds
Oxidizing agents
tertiary amines
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Summary:An approach has been developed for the amidation (halogenation) of tertiary arylamines by electrophilic activation using N‐haloimide/amides. Several control experiments have been performed, and the coupling reaction outcomes indicated that the N‐haloimide/amide brings three major functions, including electrophilic activation, aromatic halogenation and nucleophilic nitrogen sources. This cascade reaction features simple manipulation, requires no additional catalyst, oxidant or additives, and is performed under mild conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000796