Retention of men who have sex with men in a pre-exposure prophylaxis programme: survival analysis from a crossover study

Adherence to monitoring and prescription of pre-exposure prophylaxis (PrEP) is important in effectively preventing HIV infection. We aimed to establish the retention rate of men who have sex with men (MSM) who enrolled in a PrEP implementation study in Hong Kong, China. Our study was a survival anal...

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Bibliographic Details
Published in:The Lancet (British edition) 2020-11, Vol.396, p.S4-S4
Main Authors: Kwan, Tsz Ho, Lui, Grace Chung Yan, Lee, Krystal Chi Kei, Lam, Teddy Tai Ning, Wong, Ngai Sze, Chan, Denise Pui Chung, Lee, Shui Shan
Format: Article
Language:English
Subjects:
Anal sex
Analysis
Bivariate analysis
Creatinine
Data analysis
Gays & lesbians
Health risks
Hepatitis B
HIV
HIV infection
Human immunodeficiency virus
Inclination
Medical research
Medicine, Experimental
Mens health
Prophylaxis
Regression analysis
Research ethics
Retention
Risk taking
Sexual behavior
Sexually transmitted diseases
STD
Survival
Survival analysis
Virus diseases
Viruses
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Summary:Adherence to monitoring and prescription of pre-exposure prophylaxis (PrEP) is important in effectively preventing HIV infection. We aimed to establish the retention rate of men who have sex with men (MSM) who enrolled in a PrEP implementation study in Hong Kong, China. Our study was a survival analysis of a crossover study. A research clinic was set up in the teaching hospital of the university to recruit participants through community-based organisations or by self-referral. Participants were randomly assigned by block randomisation with a block size of four to two groups during the study period (32 weeks split into two 16-week phases); in the first group, participants were asked to take PrEP every day for the first 16 weeks then on demand for the remaining 16 weeks, and in the second group, participants took PrEP on demand for the first 16 weeks then ever day for the remaining 16 weeks. Eligible participants were adult HIV-negative MSM with a history of high HIV-risk behaviours or sexually transmitted infections in the preceding 6 months and an inclination to practice condomless sex in the coming 6 months. The exclusion criteria were hepatitis B virus infection, creatinine clearance lower than 60 mL per min, with or without mental illnesses. We assessed behavioural factors associated with retention by bivariate analysis. We used cox regression to characterise participants who had dropped out of the study. The study was approved by the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee (CREC 2016.719). The trial is registered with the Centre for Clinical Research and Biostatistics, The Chinese University of Hong Kong, Hong Kong, China (trial number CUHK_CCRB00606). Between Aug 25, 2018, and Mar 23, 2019, we recruited 120 MSM. Of the 120 MSM recruited, one (
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(20)32424-7