DBU-promoted ring-opening reactions of multi-substituted donor-acceptor cyclopropanes: access to functionalized chalcones with a quaternary carbon group

A convenient and straightforward strategy to synthesize Z -configuration chalcones with alkylcyanoacetate subunits via DBU-promoted ring-opening reactions of multi-substituted D-A cyclopropanes has been developed. This reaction did not require a transition metal catalyst and extra solvent, and haloa...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2020-11, Vol.18 (45), p.921-9215
Main Authors: Luo, Naili, Liu, Jiamin, Wang, Shan, Wang, Cunde
Format: Article
Language:English
Subjects:
Alkylation
Catalysts
Crystallography
Organic compounds
Reagents
Ring opening
Solvents
Substitutes
Transition metals
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A convenient and straightforward strategy to synthesize Z -configuration chalcones with alkylcyanoacetate subunits via DBU-promoted ring-opening reactions of multi-substituted D-A cyclopropanes has been developed. This reaction did not require a transition metal catalyst and extra solvent, and haloalkanes acted as both an alkylation reagent and solvent. A strategy to synthesize highly stereoselective chalcones with alkylcyanoacetate subunits via DBU-promoted ring-opening reactions of multi-substituted D-A cyclopropanes has been developed without the requirement of a transition metal catalyst and extra solvent.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob01895c