Fluoride absorption, transportation and tolerance mechanism in Camellia sinensis, and its bioavailability and health risk assessment: a systematic review

• Published in: Journal of the science of food and agriculture 2021-01, Vol.101 (2), p.379-387
• Main Authors: Peng, Chuan‐yi, Xu, Xue‐feng, Ren, Yin‐feng, Niu, Hui‐liang, Yang, Yun‐qiu, Hou, Ru‐yan, Wan, Xiao‐chun, Cai, Hui‐mei
• Format: Article
• Language: English
• Subjects: Absorption; absorption and transportation; Aluminum; Aluminum - analysis; Aluminum - metabolism; Anion channels; Beverages; Bioavailability; Biological Availability; Biological Transport; Camellia sinensis; Camellia sinensis - chemistry; Camellia sinensis - metabolism; Cell Wall - chemistry; Cell Wall - metabolism; Cell walls; Diet; Dietary Exposure - adverse effects; Dietary Exposure - analysis; Exposure; fluoride; Fluorides; Fluorides - analysis; Fluorides - metabolism; Health risks; Humans; Ion channels; Leaves; Magnesium; Magnesium chloride; Orchards; Plant extracts; Plant Leaves - chemistry; Plant Leaves - metabolism; Plant roots; Plantations; Risk Assessment; Soil - chemistry; Tea; Tea - chemistry; tolerance mechanism; Transportation; Xylem
• ISSN: 0022-5142; 1097-0010
• DOI: 10.1002/jsfa.10640

Tea is the one of the most popular non‐alcoholic caffeinated beverages in the world. Tea is produced from the tea plant (Camellia sinensis (L.) O. Kuntze), which is known to accumulate fluoride. This article systematically analyzes the literature concerning fluoride absorption, transportation and fluoride tolerance mechanisms in tea plants. Fluoride bioavailability and exposure levels in tea infusions are also reviewed. The circulation of fluoride within the tea plantation ecosystems is in a positive equilibrium, with greater amounts of fluoride introduced to tea orchards than removed. Water extractable fluoride and magnesium chloride (MgCl2) extractable fluoride in plantation soil are the main sources of absorption by tea plant root via active trans‐membrane transport and anion channels. Most fluoride is readily transported through the xylem as F−/F–Al complexes to leaf cell walls and vacuole. The findings indicate that tea plants employ cell wall accumulation, vacuole compartmentalization, and F–Al complexes to co‐detoxify fluoride and aluminum, a possible tolerance mechanism through which tea tolerates higher levels of fluoride than most plants. Furthermore, dietary and endogenous factors influence fluoride bioavailability and should be considered when exposure levels of fluoride in commercially available dried tea leaves are interpreted. The relevant current challenges and future perspectives are also discussed. © 2020 Society of Chemical Industry