Modular Reconfigurable DNA Origami: From Two‐Dimensional to Three‐Dimensional Structures

DNA origami enables the manipulation of objects at nanoscale, and demonstrates unprecedented versatility for fabricating both static and dynamic nanostructures. In this work, we introduce a new strategy for transferring modular reconfigurable DNA nanostructures from two‐dimensional to three‐dimensio...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-12, Vol.59 (51), p.23277-23282
Main Authors: Liu, Yan, Cheng, Jin, Fan, Sisi, Ge, Huan, Luo, Tao, Tang, Linlin, Ji, Bin, Zhang, Chuan, Cui, Daxiang, Ke, Yonggang, Song, Jie
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
DNA nanotechnology
DNA Origami
DNA structures
Modular structures
modular transformation
Modules
Nanostructure
nanostructures
Reconfiguration
Substrates
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Summary:DNA origami enables the manipulation of objects at nanoscale, and demonstrates unprecedented versatility for fabricating both static and dynamic nanostructures. In this work, we introduce a new strategy for transferring modular reconfigurable DNA nanostructures from two‐dimensional to three‐dimensional. A 2D DNA sheet could be modularized into connected parts (e.g., two, three, and four parts in this work), which can be independently transformed between two conformations with a few DNA “trigger” strands. More interestingly, the transformation of the connected 2D modules can lead to the controlled, resettable structural conversion of a 2D sheet to a 3D architecture, due to the constraints induced by the connections between the 2D modules. This new approach can provide an efficient mean for constructing programmable, higher‐order, and complex DNA objects, as well as sophisticated dynamic substrates for various applications. We demonstrated a new strategy for constructing modular DNA nanostructures that are reconfigurable from two‐dimensional to three‐dimensional. This strategy demonstrates an efficient means for constructing programmable, higher‐order, and complex DNA objects, as well as sophisticated dynamic substrates for various applications.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202010433