Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells

Vascular endothelial growth factor (VEGF) is well recognized as an essential component of angiogenesis and the increased proliferation and migration of endothelial cells. Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pa...

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Bibliographic Details
Published in:Food and agricultural immunology 2020-01, Vol.31 (1), p.193-204
Main Authors: Lee, Hsiang-Ping, Wang, Shih-Wei, Wu, Yang-Chang, Lin, Liang-Wei, Tsai, Fuu-Jen, Yang, Jai-Sing, Li, Te-Mao, Tang, Chih-Hsin
Format: Article
Language:English
Subjects:
Angiogenesis
Biomedical materials
Blood vessels
Bone marrow
Cartilage
Cartilage diseases
Cbfa-1 protein
Cell migration
Cell proliferation
Damage prevention
Endothelial cells
endothelial progenitor cells
Growth factors
In vivo methods and tests
Osteoarthritis
Osteoprogenitor cells
Progenitor cells
Signal transduction
Soya-cerebroside
Src protein
Vascular endothelial growth factor
Vascular endothelial growth factor receptors
VEGF
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Summary:Vascular endothelial growth factor (VEGF) is well recognized as an essential component of angiogenesis and the increased proliferation and migration of endothelial cells. Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pathological states. Soya-cerebroside, an extract from Cordyceps militaris, reduces synovial inflammation and prevents cartilage damage in an osteoarthritis model. However, the role of soya-cerebroside in VEGF-regulated EPC angiogenesis is uncertain. Records from the Oncomine database demonstrate higher levels of VEGF in cancerous tissue compared with normal tissue. This study describes VEGF-induced promotion of EPC-associated angiogenesis in vivo and how the treatment of EPCs with soya-cerebroside inhibited VEGF-facilitated migration and tube formation. The study evidence shows that the c-Src, FAK and Runx2 signalling pathways are involved in the inhibitory effects of soya-cerebroside. This novel agent may therefore be used to inhibit EPC-associated angiogenesis.
ISSN:0954-0105
1465-3443
DOI:10.1080/09540105.2020.1713055