Gut microbial metabolism of dietary fibre protects against high energy feeding induced ovarian follicular atresia in a pig model

To investigate the effects of dietary fibre on follicular atresia in pigs fed a high-fat diet, we fed thirty-two prepubescent gilts a basal diet (CON) or a CON diet supplemented with 300 g/d dietary fibre (fibre), 240 g/d soya oil (SO) or both (fibre + SO). At the 19th day of the 4th oestrus cycle,...

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Bibliographic Details
Published in:British journal of nutrition 2021-01, Vol.125 (1), p.38-49
Main Authors: Zhuo, Yong, Cao, Meng, Gong, Yuechan, Tang, Lianchao, Jiang, Xuemei, Li, Yang, Yang, Min, Xu, Shengyu, Li, Jian, Che, Lianqiang, Lin, Yan, Feng, Bin, Fang, Zhengfeng, Wu, De
Format: Article
Language:English
Subjects:
Age
Animal Feed - analysis
Animals
Apoptosis
Caspase-3
Cellulose
Diet
Diet, High-Fat - veterinary
Dietary fiber
Dietary Fiber - pharmacology
Dietary Supplements
Energy
Estrus
Female
Females
Fertility
Follicles
Follicular Atresia - drug effects
Follicular fluid
Follicular Fluid - metabolism
Gastrointestinal Microbiome - drug effects
Gene expression
High fat diet
Hogs
Intestinal microflora
Kinases
Laboratory animals
Melatonin
Melatonin - metabolism
Metabolism
Metabolites
Microbiota
Microorganisms
Models, Animal
Nutritional Endocrinology
Ovarian follicular atresia
Ovaries
Ovary - metabolism
Physiology
Serotonin
Serotonin - metabolism
Sus scrofa
Swine
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Summary:To investigate the effects of dietary fibre on follicular atresia in pigs fed a high-fat diet, we fed thirty-two prepubescent gilts a basal diet (CON) or a CON diet supplemented with 300 g/d dietary fibre (fibre), 240 g/d soya oil (SO) or both (fibre + SO). At the 19th day of the 4th oestrus cycle, gilts fed the SO diet showed 112 % more atretic follicles and greater expression of the apoptotic markers, Bax and caspase-3, and these effects were reversed by the fibre diet. The abundance of SCFA-producing microbes was decreased by the SO diet, but this effect was reversed by fibre treatment. Concentrations of serotonin and melatonin in the serum and follicular fluid were increased by the fibre diet. Overall, dietary fibre protected against high fat feeding-induced follicular atresia at least partly via gut microbiota-related serotonin–melatonin synthesis. These results provide insight into preventing negative effects on fertility in humans consuming a high-energy diet.
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114520002378