Soy Food Intake Is Inversely Associated with Newly Diagnosed Nonalcoholic Fatty Liver Disease in the TCLSIH Cohort Study

Animal studies have shown that soy protein and isoflavones can increase antioxidant capacity and improve insulin resistance, and thus ameliorate nonalcoholic fatty liver disease (NAFLD). However, only limited epidemiological studies have examined the association of soy food intake with NAFLD. We inv...

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Bibliographic Details
Published in:The Journal of nutrition 2020-12, Vol.150 (12), p.3280-3287
Main Authors: Zhang, Shunming, Kumari, Shubham, Gu, Yeqing, Wu, Xiaohui, Li, Xiaoyue, Meng, Ge, Zhang, Qing, Liu, Li, Wu, Hongmei, Wang, Yawen, Zhang, Tingjing, Wang, Xuena, Cao, Xingqi, Li, Huiping, Liu, Yunyun, Wang, Xiaohe, Sun, Shaomei, Wang, Xing, Zhou, Ming, Jia, Qiyu, Song, Kun, Sun, Zhong, Niu, Kaijun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antioxidants
Chemical compounds
China - epidemiology
Clinical trials
Cohort analysis
Cohort Studies
cross-sectional study
Diet
Epidemiology
Fatty liver
Female
Food
Food intake
Humans
Insulin
Isoflavones
Liver
Liver diseases
Male
Medical diagnosis
Men
Middle Aged
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - prevention & control
nonalcoholic fatty liver disease
Quartiles
Regression analysis
Risk Factors
soy food
Soy Foods
Soy products
Young Adult
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Summary:Animal studies have shown that soy protein and isoflavones can increase antioxidant capacity and improve insulin resistance, and thus ameliorate nonalcoholic fatty liver disease (NAFLD). However, only limited epidemiological studies have examined the association of soy food intake with NAFLD. We investigated the association between soy food intake and NAFLD in a Chinese cohort. A total of 24,622 participants aged 20–90 y were included in the study. Diet information was collected using a validated 100-item FFQ. NAFLD was defined as having fatty liver diagnosed by ultrasonography and excluding men and women who consumed >210 g alcohol/wk and >140 g/wk, respectively. Logistic regression analysis was used to assess the association of soy food intake with NAFLD. After adjustment for potential confounders, and taking those with
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/nxaa297