Detection of extended spectrum beta lactamase from multidrug resistance Escherichia coli from various clinical sample in District Peshawar, Pakistan

Gram negative bacteria's such as Escherichia coli is one of the most common community-acquired as well as the nosocomial pathogen responsible for a large number of infections. Extended-spectrum beta-lactamase producing strains of Escherichia coli has become a great therapeutic challenge to the...

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Bibliographic Details
Published in:Pure and applied biology 2020-12, Vol.9 (4), p.2383-2390
Main Author: Afzaal, Muhammad
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Ceftriaxone
Coliforms
Cotrimoxazole
Developing countries
Drug resistance
E coli
Enzymes
Escherichia coli
Gram-negative bacteria
Hospitals
Laboratories
LDCs
Multidrug resistance
Nosocomial infection
Nosocomial infections
Polymyxin B
Strains (organisms)
Urogenital system
Virulence
β Lactamase
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Summary:Gram negative bacteria's such as Escherichia coli is one of the most common community-acquired as well as the nosocomial pathogen responsible for a large number of infections. Extended-spectrum beta-lactamase producing strains of Escherichia coli has become a great therapeutic challenge to the clinicians in managing such infections. This study was carried out in order to find out multidrug-resistant Escherichia coli from various clinical samples. A total of 70 E. coli isolates were obtained from various clinical samples. These already identified samples were obtained from Lady Reading Hospital. Antibiotic susceptibility test was done by disc diffusion method. The present study shows that (55.71%) samples were ESBL positive. The percentage of isolates sensitive to current antibiotics were highest for Polymyxin b (98.57%) and highest for Ceftriaxone (12.85%). While the percentage of isolates resistant to current antibiotics were highest for that Co-trimoxazole (84.28%), and lowest for Polymyxin b (1.42%). ESBL producing strains of E. coli causes therapeutic failure and also contribute to multidrug resistance. Therefore monitoring of antimicrobial resistance in developing countries is necessary to optimize empiric treatment and the prudent use of antimicrobials.
ISSN:2304-2478
2304-2478
DOI:10.19045/bspab.2020.90252