Synthesis, antimicrobial, and mitotic toxicity evaluation of new 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acids

A series of novel 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acids were synthesized and characterized by 1H, 13C, 19F NMR, 1H‐1H‐COSY, 1H‐13C‐HSQC, NOESY, LC‐MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the All...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2021-01, Vol.58 (1), p.212-225
Main Authors: Kravtsov, Dmytro V., Voskoboinik, Oleksii Yu, Kovalenko, Serhii I.
Format: Article
Language:English
Subjects:
Acetic acid
Antiinfectives and antibacterials
Chemical analysis
Infrared analysis
NMR
Nuclear magnetic resonance
Substitutes
Synthesis
Toxicity
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Summary:A series of novel 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acids were synthesized and characterized by 1H, 13C, 19F NMR, 1H‐1H‐COSY, 1H‐13C‐HSQC, NOESY, LC‐MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the Allium test procedure. The 2‐(6‐(pentafluorophenyl)benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acid inhibited mitotic spindle formation, which resulted in significant cytotoxic effect for meristematic cells of Allium cepa l. roots. In a preliminary antimicrobial evaluation, only Streptococcus pyogenes and Candida albicans were slightly susceptible to some of the synthesized compounds.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4161