Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms

Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity and inflammation are thought to be prominent in the aetiology of depression. Although meta-analyses have confirmed this relationship, there is considerable variability in the effect sizes across studies. This could be attributed to a differenti...

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Bibliographic Details
Published in:Molecular psychiatry 2020-05, Vol.25 (5), p.1130-1140
Main Authors: Iob, Eleonora, Kirschbaum, Clemens, Steptoe, Andrew
Format: Article
Language:English
Subjects:
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Affect
Aged
Aging
Analysis
Behavioral Sciences
Biological Psychology
Biomarkers
C-reactive protein
C-Reactive Protein - analysis
Chronic diseases
Chronic illnesses
Cognition
Cognitive ability
Corticosteroids
Depression - physiopathology
Depression - psychology
Depression, Mental
Female
Hair
Hair - chemistry
Hormones
Humans
Hydrocortisone
Hydrocortisone - analysis
Hyperactivity
Hypothalamic-pituitary-adrenal axis
Hypothalamo-Hypophyseal System - physiopathology
Hypothalamus
Inflammation
Inflammation - physiopathology
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Mental depression
Neurosciences
Pharmacotherapy
Pituitary
Psychiatry
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