Biomimetic Anti-PD-1 Peptide-Loaded 2D FePSe 3 Nanosheets for Efficient Photothermal and Enhanced Immune Therapy with Multimodal MR/PA/Thermal Imaging

• Published in: Advanced science 2021-01, Vol.8 (2), p.2003041
• Main Authors: Fang, Xueyang, Wu, Xianlin, Li, Zhendong, Jiang, Lijun, Lo, Wai-Sum, Chen, Guanmao, Gu, Yanjuan, Wong, Wing-Tak
• Format: Article
• Language: English
• Subjects: Ablation; Antigens; Apoptosis; Cancer therapies; Efficiency; Immunotherapy; Ligands; Magnetic resonance imaging; Nanomaterials; Peptides; Physiology; Proteins; Spectrum analysis; Transmission electron microscopy; Tumors
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202003041

Metal phosphorous trichalcogenides (MPX ) are novel 2D nanomaterials that have recently been exploited as efficient photothermal-chemodynamic agents for cancer therapy. As a representative MPX , FePSe has the potential to be developed as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) agents due to the composition of Fe and the previously revealed PA signal. Here, a FePSe -based theranostic agent, FePSe @APP@CCM, loaded with anti-PD-1 peptide (APP) as the inner component and CT26 cancer cell membrane (CCM) as the outer shell is reported, which acts as a multifunctional agent for MR and PA imaging and photothermal and immunotherapy against cancer. FePSe @APP@CCM induces highly efficient tumor ablation and suppresses tumor growth by photothermal therapy under near-infrared laser excitation, which further activates immune responses. Moreover, APP blocks the PD-1/PD-L1 pathway to activate cytotoxic T cells, causing strong anticancer immunity. The combined therapy significantly prolongs the lifespan of experimental mice. The multimodal imaging and synergistic therapeutic effects of PTT and its triggered immune responses and APP-related immunotherapy are clearly demonstrated by in vitro and in vivo experiments. This work demonstrates the potential of MPX -based biomaterials as novel theranostic agents.