Nanomedicine beyond tumor passive targeting: what next?

[...]a recent paper describes the uptake of nanoparticles by tumor tissues as occurring mostly by active transport (6), in a different pathway from the previous consensus. Due to the strong contact cytotoxicity, oral administration of free doxorubicin is impossible. [...]the possible oral administra...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2020-08, Vol.15 (19), p.1819-1822
Main Authors: Figueiró Longo, João Paulo, Muehlmann, Luís Alexandre
Format: Article
Language:English
Subjects:
Cancer therapies
chemotherapy
clinical translation
clinical trials
Cytotoxicity
Drug dosages
healthcare
lipid nanoparticles
Lipids
liposome
nanomedicine
Nanoparticles
Nanotechnology
Oral administration
perspectives
pharmacokinetics
preclinical studies
Skin
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Summary:[...]a recent paper describes the uptake of nanoparticles by tumor tissues as occurring mostly by active transport (6), in a different pathway from the previous consensus. Due to the strong contact cytotoxicity, oral administration of free doxorubicin is impossible. [...]the possible oral administration, when entrapped in nanocarriers, could be an important technological revolution for the field. The main natural percutaneous routes for polar molecules applied onto the skin are the dermal appendices, namely the hair follicles, sweat ducts and sebaceous glands. Systems containing ultradeformable liposomes, ethosomes and nanoemulsions, for instance, have been shown to increase the ability of hydrophilic drugs to permeate the skin across the intercellular lipid matrix, as reviewed elsewhere (13,14).
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2020-0208