Prototype system of noninterferometric phase-contrast computed tomography utilizing medical imaging components

Grating-based x-ray phase-contrast imaging has been demonstrated to provide more information and higher-contrast images for low-Z soft tissues, compared with conventional absorption-based imaging. However, the existing Talbot–Lau phase-contrast devices are operated in either a two- or three-dimensio...

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Bibliographic Details
Published in:Journal of applied physics 2021-02, Vol.129 (7)
Main Authors: Wu, Z., Wei, W. B., Gao, K., Liu, G., Liu, G. F., Sun, H. X., Jiang, J., Wang, Q. P., Lu, Y. L., Tian, Y. C.
Format: Article
Language:English
Subjects:
Applied physics
Computed tomography
Field of view
High aspect ratio
Image contrast
Medical imaging
Optimization
Prototypes
Soft tissues
Synchrotron radiation
Synchrotrons
Tomography
X ray imagery
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Summary:Grating-based x-ray phase-contrast imaging has been demonstrated to provide more information and higher-contrast images for low-Z soft tissues, compared with conventional absorption-based imaging. However, the existing Talbot–Lau phase-contrast devices are operated in either a two- or three-dimensional mode at low energy with a small field of view and long exposure time. This is because of coherence limitations, difficulties in fabricating high aspect ratio gratings, and the slow readout speed of the detector. For preclinical or even clinical applications, a variable x-ray energy, a large field of view, and fast phase-contrast computed tomography (CT) devices are desirable. The noninterferometric grating-based phase-contrast imaging method is a good candidate, as it relaxes requirements on gratings, including grating period and aspect ratio. Based on the noninterferometric imaging principle, we constructed a prototype phase-contrast CT system, at the National Synchrotron Radiation Laboratory of the University of Science and Technology of China, with medical imaging components. This prototype system enables a large field of view and fast phase-contrast CT imaging under medical imaging energies. In this paper, the prototype system and preliminary experimental results are reported, and possible optimization for forthcoming work is also discussed.
ISSN:0021-8979
1089-7550
DOI:10.1063/5.0031392