Newer Formulations of Risperidone: Remarks About Risperidone ISM

[...]as we already reported, the Risperidone ISM® product is reconstituted to an injectable suspension whose polymeric component precipitates in situ after an intramuscular injection, resulting in the formation of an implant, by solvent diffusion to body fluids. Risperidone is entrapped within that...

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Bibliographic Details
Published in:CNS drugs 2020-10, Vol.34 (10), p.1087-1088
Main Authors: Anta, Lourdes, Mata, Elena, Ochoa Díaz de Monasterioguren, Lourdes
Format: Article
Language:English
Subjects:
Antipsychotic Agents - adverse effects
Antipsychotics
Body fluids
Controlled release
Drug delivery systems
Drug dosages
Humans
Letter to the Editor
Medicine
Medicine & Public Health
Microparticles
Microspheres
Neurology
Neurosciences
Pharmacokinetics
Pharmacotherapy
Psychiatry
Psychopharmacology
Psychosis
Psychotic Disorders
Risperidone
Risperidone - adverse effects
Schizophrenia
Transplants & implants
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Description
Summary:[...]as we already reported, the Risperidone ISM® product is reconstituted to an injectable suspension whose polymeric component precipitates in situ after an intramuscular injection, resulting in the formation of an implant, by solvent diffusion to body fluids. Risperidone is entrapped within that implant polymeric matrix, which biodegrades slowly providing a sustained release of drug for up to 1 month [5]. [...]Risperidone ISM® is not an emulsion comprising two phases (internal and external) nor one that comprises microparticles or microspheres, as Clark and Taylor state in their article [1]. [6], what is stated is that the product results in the formation of implants, not in microparticles or microspheres as Clark and Taylor state. [...]Risperidone ISM® is not an emulsion, it does not present several phases, and it does not lead to in situ microparticles/microspheres after administration.
ISSN:1172-7047
1179-1934
DOI:10.1007/s40263-020-00762-0