A potential cause of asbestos-related granulomatosis due to adulterant contamination in a drug abuser

Drug adulterants containing contaminants have been known to cause lung disease by inhalation or intravenous intake. Talcosis due to intravenous talc injection has been widely described in the literature, whereas the hypothesis of granulomatosis due to asbestos related to adulterated cocaine injectio...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2021-02, Vol.478 (2), p.361-366
Main Authors: Lazzaro, Maria Concetta, Romanò, Sabrina, Santoro, Sergio, Camuto, Cristian, Carbone, Arnaldo, Casamassima, Rosario, Abate, Sergio, De-Giorgio, Fabio
Format: Article
Language:English
Subjects:
Adult
Adulterants
Asbestos
Asbestos - administration & dosage
Asbestos - adverse effects
Autopsy
Brief Report
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - adverse effects
Cocaine
Cocaine - administration & dosage
Cocaine - adverse effects
Cocaine-Related Disorders - complications
Contaminants
Contamination
Drug abuse
Drug Contamination
Drug Users
Fatal Outcome
Female
Fibers
Granuloma, Foreign-Body - etiology
Granuloma, Foreign-Body - pathology
Granuloma, Respiratory Tract - etiology
Granuloma, Respiratory Tract - pathology
Granulomas
Granulomatosis
Humans
Inhalation
Injection
Intravenous administration
Light microscopy
Lung diseases
Medicine
Medicine & Public Health
Optical microscopy
Pathology
Respiration
Substance Abuse, Intravenous - complications
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Description
Summary:Drug adulterants containing contaminants have been known to cause lung disease by inhalation or intravenous intake. Talcosis due to intravenous talc injection has been widely described in the literature, whereas the hypothesis of granulomatosis due to asbestos related to adulterated cocaine injection has not yet been explored. Herein, a case of pulmonary granulomatosis due to asbestos fibres related to cocaine injection in a young woman is described. Inorganic material in the lung was first individuated by light microscopy and last was identified using the SEM-EDX method. This case is unique since the occupational and passive inhalation of asbestos was excluded with absolute certainty.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-020-02863-z