Analysis of TRIM21 Genetic Variants on the Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma

Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlati...

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Bibliographic Details
Published in:Processes 2021-03, Vol.9 (3), p.495
Main Authors: Lee, Hsiang-Lin, Chien, Yi-Chung, Chiang, Whei-Ling, Wang, Hsiang-Ling, Hsueh, Kuan-Chun, Chen, Chao-Hsuan, Chen, Shuo-Chueh, Wu, Tsai-Kun, Pan, Ying-Ru, Bai, Li-Yuan, Yang, Shun-Fa, Yu, Yung-Luen
Format: Article
Language:English
Subjects:
Age
Alcohol
Alleles
Antibodies
Apoptosis
Cancer
Cell adhesion & migration
Deoxyribonucleic acid
Disease
DNA
DNA polymerase
Gene polymorphism
Genetic analysis
Genetic diversity
Hepatitis
Hepatocellular carcinoma
Immune system
Liver cancer
Metastases
Metastasis
Nucleotides
Polymerase chain reaction
Proteins
Single-nucleotide polymorphism
Smoking
Software
Viral infections
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Summary:Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlations between these SNPs and susceptibility to HCC. Two SNPs of the TRIM21 gene from 1196 controls without cancer and 394 HCC patients were analyzed using real-time polymerase chain reaction. These results were further analyzed to expound the associations between these TRIM21 polymorphisms and the risk of HCC as well as the impact of these SNPs on clinicopathological characteristics of HCC. After adjustment for other covariants, we observed that that younger patients (
ISSN:2227-9717
2227-9717
DOI:10.3390/pr9030495