0302 One Week of Recovery Sleep is Insufficient to Restore Sustained Attention Performance Following Three Weeks of Chronic Sleep Restriction

• Published in: Sleep (New York, N.Y.) N.Y.), 2020-05, Vol.43 (Supplement_1), p.A114-A114
• Main Authors: Yuan, R K, Zitting, K, Vujovic, N, Wang, W, Buxton, O, Williams, J S, Czeisler, C A, Duffy, J F
• Format: Article
• Language: English
• Subjects: Attention; Sleep
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsaa056.299

Abstract Introduction Sleep loss negatively impacts many aspects of neurobehavioral performance, including sustained attention and reaction times. However, the time course of recovery from chronic sleep restriction (CSR) is not well understood. To explore this, we assessed the effects of 3 weeks of CSR followed by 1 week of recovery on psychomotor vigilance task (PVT) performance in healthy adults. Methods 8 healthy adults (27–71; 4f) participated in a 37-day inpatient study. The study consisted of 6 baseline (BL) days with 8–16 h time-in-bed, followed by 3 weeks of CSR (5-5.6h time-in-bed at night), and 1 week of recovery (RC; 8-10h time-in-bed). Sustained attention was assessed by 10-minute visual PVTs administered every 2h starting ~5h after wake (~4/day). Linear and generalized linear mixed models were used to compare average reaction times (RT) and number of lapses, respectively, from the last 3 days of baseline, CSR, and recovery. Results Average RT was almost twice as long at the end of CSR compared to baseline (p