0117 Circadian- and Wake-Dependent Effects on Recall for Face-Name Pairs

• Published in: Sleep (New York, N.Y.) N.Y.), 2020-05, Vol.43 (Supplement_1), p.A46-A46
• Main Authors: Yuan, R K, Münch, M Y, Cain, S W, Ronda, J M, Czeisler, C A, Duffy, J F
• Format: Article
• Language: English
• Subjects: Jet lag
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsaa056.115

Abstract Introduction The ability to remember the face and name of a person we have recently met is a critical skill often impacted by cognitive impairment and Alzheimer’s disease. We used a forced desynchrony protocol to explore whether recall of recently-learned face-name pairs is affected by time awake and/or circadian phase in healthy adults. Methods 13 healthy, cognitively normal adults (20-70yrs; 7F) participated in a 39-day inpatient protocol with 3 baseline days (10h time-in-bed/24h) and a 3-week forced desynchrony (FD) segment, where they lived on a 28-h day with sleep restriction (6.5h time-in-bed/28h, equivalent to 5.6h/24h). Core body temperature was collected throughout to estimate circadian period and phase. The face-name test was administered every 4h, beginning 3h after wake. Each test included a learning session with 6 novel face-name pairs. Recall was tested 2h later, when each face was presented twice in random order, once with a correct and once with an incorrect name. Participants were asked to respond whether each face-name pair was correct. Data were averaged across 4-h circadian phase or time awake bins and normalized as a percentage of each participant’s baseline performance. Results Face-name recall varied by time awake (p