0072 GLUCOSE TOLERANCE AFTER ACUTE SLEEP DEPRIVATION, SLEEP RESTRICTION, AND RECOVERY SLEEP

Abstract Introduction: Shift-work is related to metabolic and cardiovascular disease. Sleep restriction and circadian misalignment have been shown to decrease glucose tolerance. Since shift-work is often associated with a combination of sleep restriction, total sleep deprivation and intermittent rec...

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Published in:Sleep (New York, N.Y.) N.Y.), 2017-04, Vol.40 (suppl_1), p.A27-A28
Main Authors: Elmenhorst, E, Hennecke, E, Lange, D, Fronczek, J, Bauer, A, Elmenhorst, D, Aeschbach, D
Format: Article
Language:English
Subjects:
Chromium
Glucose
Metabolism
Sleep deprivation
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Summary:Abstract Introduction: Shift-work is related to metabolic and cardiovascular disease. Sleep restriction and circadian misalignment have been shown to decrease glucose tolerance. Since shift-work is often associated with a combination of sleep restriction, total sleep deprivation and intermittent recovery sleep we tested (i) whether acute sleep deprivation and repeated sleep restriction exhibit similar effects on glucose tolerance, (ii) whether one night of recovery sleep after repeated sleep restriction is sufficient to restore glucose tolerance, and (iii) whether the effects of acute sleep deprivation and prior sleep restriction are cumulative. Methods: Morning oral glucose tolerance (OGTT: 75g dextrose/300ml water; >10h fasting) was tested during a 12-day inpatient study in an intervention group (IG) (N=18; 9 females, mean age 26 ± 3 years, BMI 23.2 ± 2.0) and a control group (CG) (N=9; 3 females, mean age 25 ± 5 years, BMI 23.5 ± 3.4). In the IG OGTTs were run after (i) two nights of baseline sleep (8h TIB), (ii) five nights of sleep restriction (5h TIB), (iii) one night of recovery (8h TIB), and (iv) 24h of sustained wakefulness following recovery. In the CG OGTTs were taken at the same time points except that TIB was 8h for all sleep episodes. Blood samples were taken immediately prior to the OGTT and every 30min thereafter for 120min. Mixed ANOVAs with Tukey adjustment compared glucose levels in each group between interventions. Results: Glucose tolerance decreased after five nights of sleep restriction: compared to baseline, blood glucose stayed elevated 60min (Δ19.1 ± 6.2 mg/dl (SE), p
ISSN:0161-8105
1550-9109
DOI:10.1093/sleepj/zsx050.071