Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing

Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions. Electrical stimulation at the wound site is a compelling strategy for skin wound repair. However, there has been an urgent need for wearable and poin...

Full description

Saved in:
Bibliographic Details
Published in:Nano research 2020-09, Vol.13 (9), p.2525-2533
Main Authors: Du, Shuo, Zhou, Nuoya, Gao, Yujie, Xie, Ge, Du, Hongyao, Jiang, Hao, Zhang, Lianbin, Tao, Juan, Zhu, Jintao
Format: Article
Language:English
Subjects:
Adhesives
Angiogenesis
Atomic/Molecular Structure and Spectra
Biomedicine
Biotechnology
Chemistry and Materials Science
Collagen
Condensed Matter Physics
Electric power generation
Electrical stimuli
Fluorides
Growth factors
Hydrogels
Materials Science
Mechanical properties
Nanofibers
Nanogenerators
Nanotechnology
Permeability
Piezoelectricity
Polyvinylidene fluorides
Research Article
Skin
Stimulation
Vinylidene fluoride
Wearable technology
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions. Electrical stimulation at the wound site is a compelling strategy for skin wound repair. However, there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue. Herein, we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator (HPSP) for promoting skin wound healing, which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride) nanofibers. The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion. We show that the HPSP not only promotes fibroblast proliferation and migration in vitro , but also effectively facilitates the collagen deposition, angiogenesis, and re-epithelialization in vivo with the increased expressions of crucial growth factors. The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3, greatly accelerating the healing process. This patch can serve as wearable and real-time electrical stimulation devices, potentially useful in clinical applications of skin wound healing.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-020-2891-9