Effect of the anionic center hydration on the activation barrier of intramolecular nucleophilic addition in αβ-unsaturated oximes

The mechanism of intramolecular nucleophilic addition in αβ-unsaturated oximes, as well as the effect of the anionic center hydration with one and two water molecules on the activation barriers of intramolecular cyclization, was studied using the B2PLYP-D2/6-311+G**//B3LYP(D)/6-31+G* method with the...

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Bibliographic Details
Published in:Journal of physics. Conference series 2021-03, Vol.1847 (1), p.12057
Main Authors: Pradedova, A G, Kobychev, V B
Format: Article
Language:English
Subjects:
Hydration
Ions
Oximes
Physics
Solvation
Water chemistry
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Summary:The mechanism of intramolecular nucleophilic addition in αβ-unsaturated oximes, as well as the effect of the anionic center hydration with one and two water molecules on the activation barriers of intramolecular cyclization, was studied using the B2PLYP-D2/6-311+G**//B3LYP(D)/6-31+G* method with the solvation effects included within the SMD model. The activation barrier for nucleophilic addition of the anionic center of the oxime group to the carbon skeleton of 3-ethyl-N-hydroxy-5-phenylpenten-3-imine-2 is about 21 kcal/mol. During the hydration of the anionic center with one water molecule, a strong complex is formed, which increases the activation barrier by ∼ 6 kcal / mol. The addition of a second water molecule leads to an even higher activation barrier ( ΔG ‡ = 28 kcal/mol), but promotes the binding of the leaving hydroxide ion.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1847/1/012057