Symbiotic assembly of peptide nano-mosaics at solid interfaces

The spontaneous co-organization of distinct biomolecules at interfaces enables many of Nature's hierarchical organizations involving both hard and soft materials. Engineering efforts to mimic such hybrid complexes rely on our ability to rationally structure biomolecules at inorganic interfaces....

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Bibliographic Details
Published in:Nanoscale 2021-04, Vol.13 (16), p.7735-7743
Main Authors: Jorgenson, Tyler D, Zareie, Hadi M, Sarikaya, Mehmet, Overney, René M
Format: Article
Language:English
Subjects:
Assembly
Biomolecules
Crystallography
Graphite
Miscibility
Mosaics
Nanotechnology
Nucleation
Peptides
Substrates
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Summary:The spontaneous co-organization of distinct biomolecules at interfaces enables many of Nature's hierarchical organizations involving both hard and soft materials. Engineering efforts to mimic such hybrid complexes rely on our ability to rationally structure biomolecules at inorganic interfaces. Control over the nanoscale structure of patterned biomolecules remains challenging due to difficulties in controlling the multifarious interactions involved. This work discusses binary peptide assembly as a means to fabricate biomolecular nano-mosaics at graphite surfaces with predictable structures. Distinct peptide-substrate interactions lead to divergent crystallographic growth directions, molecular scale immiscibility, and a symbiotic assembly phenomenon. We present a symbiotic assembly model that accurately predicts the binary assembly structure relying solely on the constituent peptide nucleation kinetics and molar fractions. The ability to tune such biomolecular nano-mosaic structures facilitates the bottom up fabrication of high-density, multifunctional interfaces for nanotechnology. Binary assembly of peptides with unique crystallographic assembly directions enables the formation of complex biomolecular mosaics at solid surfaces.
ISSN:2040-3364
2040-3372
DOI:10.1039/d0nr07208g