Adverse events among adult Medicaid enrollees with opioid use disorder and co-occurring substance use disorders

•Adults misusing both opioids and other drugs had higher risk of adverse events.•Risk for adverse events varied in magnitude by substance use disorder combination.•Those misusing opioids and other drugs were more likely to have a mental disorder.•Multisubstance use should be screened for and treated...

Full description

Saved in:
Bibliographic Details
Published in:Drug and alcohol dependence 2021-04, Vol.221, p.108555, Article 108555
Main Authors: O’Brien, Peggy, Henke, Rachel Mosher, Schaefer, Mary Beth, Lin, Janice, Creedon, Timothy B.
Format: Article
Language:English
Subjects:
Adults
Adverse
Cocaine
Comorbidity
Critical incidents
Dependent variables
Diagnosis
Disorders
Drug addiction
Drug overdose
Drug use
Government programs
Medicaid
Medical diagnosis
Medicare
Narcotics
Opioid use disorder
Opioids
Overdose
Poisoning
Polysubstance use
Prescription drugs
Risk
Substance use
Substance use disorder
Suicidal ideation
Suicide
Suicides & suicide attempts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Adults misusing both opioids and other drugs had higher risk of adverse events.•Risk for adverse events varied in magnitude by substance use disorder combination.•Those misusing opioids and other drugs were more likely to have a mental disorder.•Multisubstance use should be screened for and treated to prevent adverse events. It is common for adults with opioid use disorder (OUD) to misuse additional substances, and these individuals may be particularly at risk for adverse events, including mortality. Less is known about how continued receipt of prescription opioids or risk of adverse events (e.g., suicidality, overdose, poisoning) differs for people with co-occurring OUD and additional substance use disorders (SUDs). We conducted a retrospective study using IBM® MarketScan® Multi-State Medicaid Database enrollment/claims data. We used logistic regression to measure the association between sample characteristics and our dependent variables. The sample consisted of non-Medicare-eligible adults aged 18–64 years who were continuously enrolled in Medicaid in 2016–2017 with an OUD diagnosis on at least one claim in 2016. Adults with OUD and a co-occurring SUD were more likely than adults with OUD only to have an opioid-related poisoning event (odds ratio [OR] = 1.488, p = .0052), all-cause poisoning (OR = 1.756, p 
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2021.108555