Special emphasis on the therapeutic potential of microparticles with antidiabetic effect: Trends and possible applications

• Published in: Trends in food science & technology 2021-05, Vol.111, p.442-462
• Main Authors: de Oliveira, Williara Queiroz, Neri-Numa, Iramaia Angélica, Arruda, Henrique Silvano, Lopes, Amanda Tibães, Pelissari, Franciele Maria, Barros, Francisco Fábio Cavalcante, Pastore, Glaucia Maria
• Format: Article
• Language: English
• Subjects: Animal models; Bioavailability; Diabetes; Diabetes mellitus; Drying; Edema; Encapsulation; Flavonoids; Global health; Hyperglycemia; In vivo methods and tests; Insulin resistance; Ischemia; Membrane permeability; Metabolic disorders; Microparticles; Oxidative stress; Public health; Spray drying; Stability; Trends
• ISSN: 0924-2244; 1879-3053
• DOI: 10.1016/j.tifs.2021.02.043

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia. It is a growing global health problem, which results in a stroke, cardiac ischemia, irreversible macular edema, and other comorbidities. In this context, flavonoids have emerged as a potential tool to prevent the onset and/or progression of diabetes and its associated comorbidities. However, the main disadvantage of flavonoid compounds is their restricted bioavailability, caused mainly by their low stability and solubility in gastrointestinal environments, in addition to limited membrane permeability. The aim of this study is to show the fundamental role of encapsulation of flavonoids against diabetes and its associated comorbidities, presenting recent advances and pioneering research on these particles with animal models and human trials. In addition, the role of encapsulation systems to increase stability and bioavailability will be discussed. Most in vitro and in vivo studies in the literature suggest that the use of encapsulated flavonoids, instead of free compounds, can be effectively used to relieve the symptoms of diabetes. The spray drying technique is an alternative for the encapsulation of flavonoids; however, some limitations will be highlighted. This review will provide valuable information that may be useful for identifying trends in the production of natural particles with antidiabetic properties, confirmed by several studies published to date. •In 2030, it is estimated that 578 million people will have diabetes mellitus.•Antidiabetic drugs available on the market cause numerous side effects.•Flavonoid may be useful in the management of diabetes mellitus.•Flavonoids modulate several diabetes signaling pathways.•Encapsulation improves bioavailability and the targeted delivery of flavonoids.