Diagnosis of solid tumors in infants by fine‐needle aspiration cytology: 5years retrospective study from a tertiary care oncology center in South India

IntroductionNeuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytolog...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostic cytopathology 2021-06, Vol.49 (6), p.743-752
Main Authors: Mukundapai, Malathi, Agrawal, Mohit, Nargund, Ashwini, Geeta V Patil Okaly, Kavitha, B L, Padma, M, Madhu, S D
Format: Article
Language:English
Subjects:
Cellular biology
Rhabdomyosarcoma
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IntroductionNeuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost‐effective for solid tumor diagnosis. This study aims to evaluate the role of FNAC in the diagnosis of various infantile solid tumors.MethodsIn this retrospective study, 61 cases of FNA of infant solid tumors were retrieved from the cytology archives over a period of 5 years from January 2013 to December 2017. Cytomorphology was studied and immunohistochemistry on cell block was performed wherever feasible. Histopathological correlation was done in 19 cases.ResultsOf the 61 cases studied, 60 cases were included in the study of which 35 were male and 25 were female. Infantile solid tumors constituted 7.3% of all pediatric solid tumors reported in cytopathology division of our Institute. The most common final diagnosis was NB (15, 25%) followed by HBL (13, 21.6%), WT (10, 16.6%), RMS (nine, 15%) and GCT (nine, 15%). The commonest site was abdominal‐pelvic (42, 70%). A definitive independent diagnosis could be made on FNA in 48 cases (80%). Follow‐up was done for 1.5 to 4 years (mean 26 months). The highest and lowest mortality was noted in NB (64.3%) and WT (12.5%) respectively.ConclusionThis study concludes that FNAC can be adopted as a diagnostic modality in infant solid tumors.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.24735