Oligorecurrent prostate cancer treated with metastases-directed therapy or standard of care: a single-center experience

• Published in: Prostate cancer and prostatic diseases 2021-06, Vol.24 (2), p.514-523
• Main Authors: Boeri, Luca, Sharma, Vidit, Kwon, Eugene, Stish, Bradley J., Davis, Brian J., Karnes, R. Jeffrey
• Format: Article
• Language: English
• Subjects: 692/699/67/1059; 692/699/67/589/466; Aged; Androgen Antagonists - therapeutic use; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Care and treatment; Castration; Combined Modality Therapy; Deprivation; Follow-Up Studies; Humans; Lymph Node Excision; Lymph nodes; Lymphatic Metastasis; Lymphatic system; Male; Medical research; Medicine, Experimental; Metastases; Metastasis; Middle Aged; Mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; PET imaging; Positron emission; Positron emission tomography; Prognosis; Prostate cancer; Prostatectomy - methods; Prostatic Neoplasms - pathology; Prostatic Neoplasms - therapy; Reproductive Medicine; Retrospective Studies; Standard of care; Standard of Care - statistics & numerical data; Survival; Survival Rate; Therapy
• ISSN: 1365-7852; 1476-5608
• DOI: 10.1038/s41391-020-00307-y

Background: The optimal treatment for oligorecurrent prostate cancer (PCa) is a matter of debate. We aimed to assess oncologic outcomes of patients treated with metastasis-directed therapy (MDT) vs. androgen deprivation therapy (ADT) for oligorecurrent PCa. Methods: We analyzed data from patients with oligorecurrent PCa treated with ADT ( n  = 121), salvage lymph node dissection (sLND) ( n  = 191) or external beam RT (EBRT) ( n  = 178). Radiological recurrence (RAR) was defined as a positive positron emission tomography imaging after MDT or ADT. Second-line systemic therapies (SST) were defined as any systemic therapy administered for progression. Oncologic outcomes were evaluated separately for patients with node-only or bone metastases. Kaplan–Meier method was used to assess time to RAR, SST, and cancer-specific mortality (CSM). Predictors of RAR, SST, and castration-resistant PCa (CRPCa) were assessed with Cox regression analyses. Results: Overall, 74 (22.6%), 63 (19.2%), and 191 (58.2%) patients were treated with ADT, EBRT, and sLND for lymph node-only recurrence. Both sLND (HR 0.56, 95% CI 0.33–0.94) and EBRT (HR 0.46, 95% CI 0.25–0.85) were associated with better RAR than ADT. Similarly, sLND (HR 0.25, 95% CI 0.13–0.50) and EBRT (HR 0.41, 95% CI 0.19–0.87) were associated with longer SST, as compared with ADT. Similar results were found for CRPCa status. Oncologic outcomes were similar between sLND and EBRT. MDT was not associated with survival benefit in patients with bone metastases as compared with ADT. Conclusions: sLND and EBRT were associated with better RAR, SST, and CRPCa-free survival as compared with ADT in patients with oligometastatic PCa nodal recurrence. No difference in survival outcomes was observed between sLND and EBRT. MDT was not associated with survival benefit in patients with bone metastases, as compared with ADT.